Diego Forlan's half-volley from 17 yards out bounced over-and-around Hand-Jörg Butt and into the German net, giving Uruguay a 2-1 lead in the 51st minute.
For Forlán, it is his fifth goal in seven World Cup 2010 matches, moving him even with Thomas Müller, David Villa and Wesley Sneijder for the tournament lead.
Forlan's opportunity came after build-up play down Uruguay's right flank led to his opportunity at the edge of the penalty area, toward the right side of goal. Forlan had to bring his right foot high onto the ball to get on top of his shot. He did, driving the ball into the ground, a shot that bounce high and to the left of Butt, giving Uruguay their first lead of the match.