Napoli finished with four RBI for the Angels, who captured the opener of this brief two-game set and have won four of their last five games overall.
Sean O'Sullivan was recalled from Triple-A Salt Lake late Monday and pitched six strong innings. O'Sullivan (1-0) replaced Scott Kazmir, who was placed on the 15-day disabled list due to a strained left shoulder, and allowed two runs on two hits with four strikeouts to earn the win.
Nick Swisher hit his 17th home run of the season in the losing effort.
The Yankees grabbed an early lead with a pair of runs in the first inning. After Swisher's one-out solo homer, Mark Teixeira drew a walk and moved to third on a double by Alex Rodriguez. Robinson Cano then walked to load the bases and a groundout to the right side of the infield by Jorge Posada allowed Teixeira to cross the plate.
An RBI single by Izturis in the top of the second cut the Angels' deficit in half, and another RBI base hit -- this one off the bat off Torii Hunter -- in the third knotted the score.
In the top of the fourth, Juan Rivera laced a one-out single before Izturis stepped to the plate and belted his third home run of the season over the wall in right field.
In the sixth, Napoli turned on a Hughes fastball and blasted it over the right-field wall. The two-run shot also scored Matsui, who led off the frame with a walk.
New York manager Joe Girardi was ejected in the bottom of the sixth because he argued with umpires after Teixeira was called out on a close play at first base.
The Angels gained a bit of insurance in the seventh. Hunter drew a two-out walk and Chan Ho Park entered from the New York bullpen. Matsui greeted him with a home run to right field for an 8-2 advantage.
Los Angeles reliever Scot Shields worked around a first-and-third situation by inducing an inning-ending groundout off the bat of Brett Gardner in the seventh and Francisco Rodriguez did the same in the eighth. With runners on the corners and two outs, Rodriguez got Cano to fly out to left field.
A two-run single by Napoli in the top of the ninth capped the scoring.
Hughes is now 3-1 lifetime against the Angels (four starts)...The Angels outhit the Yanks, 14-6...New York was 1-for-7 with runners in scoring position...Swisher now has 54 RBI in 2010...Angels outfielder Bobby Abreu was thrown out twice trying to steal by Posada.