Peter King of Sports Illustrated likes the 49ers to win big:
St. Louis Rams (2-9) at San Francisco 49ers (9-2)
Tell me how the Niners are losing the second seed in the NFC with this remaining sked: Rams, at Cards, Steelers, at Seahawks, at Rams. Say they end up 13-3 and the Saints end up 13-3. Saints have three conference losses. Niners have one, maybe two, conference losses. No head-to-head play this year. It's beginning to look a lot like a bye week, Niners.
The folks over at ESPN seem to like the 49ers across the board.
Peter Schrager of Fox Sports likes the 49ers to win:
St. Louis at San Francisco: Ten days to prepare, angry over getting manhandled in the Harbaugh Bowl on Thanksgiving and poised to wrap the division up by December, San Francisco should take care of business vs. the struggling Rams on Sunday. By the way, did you know Jim and John Harbaugh are brothers? Yeah, it's true. Wait, did you know their dad coached football, too? I know! Crazy right? The media sure knows how to beat the hell out of a story, huh?
The Pick: 49ers 24, Rams 13