Edinson Volquez, meanwhile, was touched up for seven runs in 5.1 innings. Volquez allowed three home runs - back-to-back solo shots by Matt Holliday and Lance Berkman in the first inning, and a three-run bomb by Holliday in the fifth, which gave Holliday his first multi-homer game of the season.
With the Cardinals' win and the Reds' loss, St. Louis holds a 1.5-game lead on the N.L. Central. The Pittsburgh Pirates, who defeated the Houston Astros Tuesday, are now in second place, followed by the Milwaukee Brewers and the Reds.