The Buffalo Bills are picking 10th in the 2012 NFL draft and they can go in a bunch of different directions, including linebacker, offensive line or receiver. SB Nation's Bills blog, Buffalo Rumblings, opts for the latter of the three and predicts the Bills will select Notre Dame WR Michael Floyd.
You could ask your grandmother this same question and be just as likely to get the correct answer. This is not a draft class that's particularly top-heavy on talent, and the Bills are in a spot where they're likely going to want to trade down, if possible, to maximize value. If they're stuck at No. 10 overall, right now, the most likely option seems to be Notre Dame wide receiver Michael Floyd, but there are at least a dozen guys that would make sense for the team.