This matchup figures to be a classic quarterback duel, with both teams struggling to move the ball on the ground through the first three games of the season. Peyton Manning will look to bounce back from a shaky outing vs. the Houston Texans.
ESPN's pickers have Denver winning the game across the board. CBS Sports' Jason La Canfora is the lone backer of the Raiders among their group, and all of the Yahoo! Sports picks that are registered to this point from their crew have the game favoring the Broncos in a landslide.
But given the unpredictable nature of the league, anything can happen. The Raiders have been a two-faced team, showing signs of ineptitude in San Diego and flashes of brilliance late in the game vs. the Pittsburgh Steelers.