In 10 tournament games against 1-seeds since 1996, the 4-seed Michigan State Spartans are just 3-7 SU. The Spartans are favored to add another win to that record as 2-point chalk Friday against the 1-seed Virginia Cavaliers. This is only the second time that a 4-seed has been favored over a 1-seed since 1996; 4-seed Louisville beat 1-seed Washington the last time it happened in 2005.
Earlier in the evening, the 3-seed Iowa State Cyclones are a 2-point favorite going up against the 7-seed Connecticut Huskies.
In defeating Harvard 80-73 on Saturday, Michigan State improved to 6-1 SU and ATS over its last seven games. The UNDER is 4-0 in Michigan State's last four Sweet 16 appearances.
Virginia bounced back nicely from a mediocre game against Coastal Carolina with a 78-60 blowout against Memphis. The Cavaliers are 18-1 SU over their last 19 games and 6-2-1 ATS over their last nine.
Top seeds are 12-4 SU in their last 16 games against 4-seeds, according to the Odds Shark searchable NCAA basketball database.
Madison Square Garden in New York City hosts the Michigan State vs. Virginia game at 9:57 p.m. ET on Friday. Beforehand, the Connecticut vs. Iowa State betting matchup is set to tip off at 7:27 p.m.
Iowa State was undeterred by the loss of Georges Niang to injury, defeating North Carolina 85-83 on Sunday to advance to the Sweet 16. The Cyclones are a perfect 6-0 SU and ATS in their last six games with five of those games going OVER the total. Iowa State is 6-2 ATS in its last eight tournament games.
Connecticut upset 2-seed Villanova 77-65 Saturday as a 4.5-point underdog. The Huskies are 4-1 SU and ATS over their last five games with the only loss coming to Louisville. UConn is 7-2 ATS in its last nine NCAA tournament games.
The UNDER is 13-3 in Connecticut's last 16 games, but the total has gone OVER in both of its tournament games so far.
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