Louisville ended the weekend as the third-ranked team in the nation after beating South Florida, 64-38, on Saturday. Duke's loss to NC State on that day, coupled with Michigan's loss to Ohio State on Sunday, may result in the Cardinals leapfrogging both teams, despite Louisville's five-point loss to the Blue Devils earlier this season.
The Cardinals will face a UConn team that toppled No. 17 Notre Dame on the road on Saturday, ending the Fighting Irish's 12-game winning streak. Tyler Olander and Shabazz Napier combined to score 35 points on 16-of-22 shooting in the victory.
Louisville and UConn will tip off at 7 p.m. ET on ESPN.
In other top 25 action, the No. 6 Kansas Jayhawks face a bit of a test with the Baylor Bears visiting Lawrence. After a close loss to No. 13 Gonzaga on the road, Baylor bounced back to win its first three Big 12 games, including an 82-48 thrashing of Texas Tech in Lubbock.
Kansas avoided an upset in its conference opener, getting past Iowa State in overtime on Jan. 9. The Jayhawks followed that with a 60-46 win over Texas Tech on Saturday.
Kansas and Baylor will get started after the completion of the Louisville-UConn game on ESPN.