Tom Izzo hasn't ever beaten Roy Williams while Williams has been at North Carolina. With the unranked Tar Heels traveling to face the top-ranked Spartans, Michigan State might have their best chance. A couple of early-season upsets have taken a bit of luster away from the matchup, as the Tar Heels plummeted out of the AP Top 25 after their latest loss, 63-59, on Sunday.
Williams and Izzo have met six times coaching their current schools, and in many of the games, the stakes have been high -- including two Final Four games. No matter what, the result has always been the same, a win for Williams and the Tar Heels. This time Izzo and the Spartans are 7-0, coming off to their best start since 2000-01. The Tar Heels have been a team of two sides this season, boasting a win over then No. 3 Louisville, but holding a loss at home to Belmont as well.
The game tips off at 9 p.m. ET and is broadcast nationally on ESPN/WatchESPN.
Here are the rest of the best games on Wednesday.
Ohio State and Maryland haven't played each other in nearly 30 years, but it'll be a good preview for what is going to come. Maryland is hopping out of the ACC to join the Big Ten next year.
Both teams are coming off their most impressive offensive outputs of the season. Jake Layman scored 27 points and Maryland shot 62 percent in a 89-62 win over Morgan State. Meanwhile, LaQuinton Ross regained his shooting touch, scoring 17 points to help Ohio State beat the North Florida Ospreys, 99-64.
Outside of a fun mascot, things probably won't be too great for the Kangaroos on Wednesday. Louisville is angry after losing its first game of the season, and will continue to take it out on unranked opponents. Usually, it isn't much of a contest, as the Cardinals have won by an average of 24.3 points against unranked opponents during their current 18-game home winning streak. UMKC is ranked No. 256 in Kenpom's defensive efficiency ratings and are coming off one of their worst efforts, allowing the Milwaukee Panthers to shoot 65 percent from the floor in their most recent loss.
The Virginia Cavaliers are sitting right on the cusp of the Top 25, and a win over Wisconsin would help cement a return in the polls next week. In previous years, this would have the looks of a defensive grindout. This year, however, Wisconsin is scoring at quite a great clip. Between Frank Kaminsky and Sam Dekker, the Badgers are a matchup nightmare. Virginia is still led by Tony Bennett, and therefore the Cavaliers know how to shut teams down. They are fourth in Kenpom's ratings for adjusted defensive efficiency ratings and are holding opponents to 37 percent shooting, good for 16th in the nation.
Pennsylvania Quakers at No. 14 Villanova Wildcats, 8 p.m. ET, FS1
Things really couldn't be going better for Villanova. They took the nation by storm, winning the Battle 4 Atlantis by upsetting both Kansas and Iowa in back-to-back games. James Bell scored 20 points to help overcome a 12-point deficit and pull out a win in overtime over the Hawkeyes for the tournament championship. The Wildcats return home for a much easier game against the Quakers, who have lost 10 straight games by double-digits to Villanova.
The Dayton Flyers used a strong showing at the Maui Invitational to propel themselves into the Top 25. It is the first time in four years the Flyers have been ranked, and they did it by surprising most everyone going into the tournament. Dayton was the least sexy of the invites, but they upset then No. 11 Gonzaga, took then No. 18 Baylor all the way down to the wire and very convincingly topped Cal to take third in the tournament. It is the first time Delaware State has faced a Top 25 opponent since losing to the Pittsburgh Panthers in 2010.