Luck is dealing with a knee injury but practiced in full on Wednesday, Thursday and Friday. He should have no trouble suiting up for Sunday's game.
Fantasy Impact: Andrew Luck has become a reliable fantasy starter in the second half of the season, and this injury shouldn't impact that too much.
Luck has a friendly matchup on Sunday against the Bills. Buffalo has given up the fourth most fantasy points to quarterbacks so far this season, so the matchup doesn't get much better. If ever there was a time to start Luck over your usual starter, this week could be it.