Jackson suffered a knee injury in last week's game against the St. Louis Rams. Jackson was unable to practice all week and won't play on Sunday. C.J. Spiller will start at running back for the Bills in Week 15.
Fantasy Impact: Fred Jackson has been an inconsistent fantasy producer this season because of multiple injuries that have caused him to miss games. Jackson has also been sharing the backfield duties with C.J. Spiller, who is having a breakout season.
The Bills have a tough matchup against the Seahawks, but Spiller is a talented enough back to keep the Bills' running game afloat.