With rookie sensation Andrew Luck, Wayne has received an abundance of targets and has helped this team tremendously. In Week 16, the Colts will take on the Kansas City Chiefs, where this tandem will have another opportunity to showcase their chemistry.
Fantasy Analysis: With the departure of Peyton Manning and the introduction of a rookie passer, Wayne was not the highly sought after WR like a Calvin Johnson, Roddy White or even a Steve Smith. Yet, he has been incredible productive this season.
Accounting for yards, catches and scores, Wayne is a reliable WR1 each and every week. Owners should start him in the fantasy finale of 2012.