Shockingly, this was not Charles' high-yardage mark this season; he rushed for 233 yards against the Saints in Week 3. Equally as shocking, the Chiefs lost despite 352 yards rushing; the most yards ever gained by a losing team.
Fantasy Impact: Charles had an absolute monster of a game in what was championship week for most fantasy leagues. He bounced back from his worst week of the season, when he only rushed for 10 yards against the Raiders last week.
If your league plays in Week 17, Charles has a tough matchup against the Broncos, but he has already rushed for 100 yards against them earlier this season. Stick with him, he's all the Chiefs have.