Manningham is dealing with a shoulder injury and missed practice all week. The 49ers will be without him against the Dolphins this week.
Fantasy Impact: Mario Manningham has 41 catches for 449 yards and one touchdown this season, so it's not like he's been setting the fantasy football world on fire. His targets will likely go to Michael Crabtree, Randy Moss or Vernon Davis this week.
Manningham can probably be dropped in most fantasy leagues, as he won't have much value in the next few weeks. There are higher upside options on the waiver wire.