Spiller suffered an ankle injury in Sunday's win over the Baltimore Ravens. He missed practice on Monday and Tuesday and got only a limited session in on Wednesday. He was officially listed as questionable for the game. Spiller has been disappointing fantasy owners so far this year, getting just 230 yards and a touchdown on 3.5 yards per carry.
Fantasy impact: Despite the short week, the Bills feel comfortable making Spiller active for the game. He may end up going on a snap count since the ankle is clearly less than 100 percent. Fred Jackson is also dealing with a knee injury, but it won't be a surprise if he leads the team in touches. Neither player is a compelling option against a Cleveland defense that shut down Ray Rice last week.