Jackson has been playing through an MCL sprain over the past few weeks, carrying the load while Spiller continues to work his way back from an ankle injury. Spiller finally sat out in Week 8 to nurse himself back to health, and his capacity remains to be seen despite being listed as active and probable in Week 9.
Fantasy Spin: For all the hype surrounding the Chiefs' defense this season -- and it's well deserved -- they have allowed 4.7 yards per carry despite allowing modest rushing totals all season. The Bills will need to rely on their backfield and hope that efficiency can translate to volume while rookie quarterback Jeff Tuel will be thrust into the starting role with E.J. Manuel and Thad Lewis injured.
In the meantime, Spiller is a boom-or-bust flex play in an unfavorable matchup, while Jackson can be penned-in as a touchdown-dependent RB2. Tashard Choice will also be involved in the mix, but remains off of fantasy radars.