This is the time of year where injuries can really make or break a team. The loss of Aaron Rodgers can make some owners feel like they're out of contention now, but there's
always normally an alternative. Keeping an active eye on key matchups can somewhat help erase the thought of major injuries.
Now is also the time for owners to be loading up on reliable starters. Two-for-one deals become your best friend, if you can spare it. Depth isn't the key anymore.
If you are struggling with your lineup, though, take a look at some of each position's best and worst plays for Week 10.
Eli Manning (vs. Raiders): Did you watch Nick Foles throw seven touchdown passes against the Raiders last weekend? While Manning has certainly been a disappointment to fantasy owners this season, he can rejuvenate his fantasy stock coming off a bye week.
Ryan Tannehill (vs. Buccaneers): With all the turmoil surrounding the Dolphins and two members of their offensive line, it might be a good idea to bet on this unit for Week 10. Tannehill was incredibly accurate last week against the Bengals, and he's now facing a Bucs defense that allows the sixth-most points to opposing quarterbacks.
Terrelle Pryor (at Giants): Those rushing yards never get old. Pryor still needs to do some work to through the air to improve his fantasy stock, but his matchup against New York should help in that area. Think the Giants have been solid against the pass lately? They faced Matt Barkley and Josh Freeman. Don't be fooled.
Mike James (vs. Dolphins): James exploded for 158 yards rushing against the Seahawks last week. Now he takes on a Dolphins defense that hemorrhages points to opposing backs. No luck for Doug Martin owners, James is getting the start again.
Chris Johnson (vs. Jaguars): CJ?K is finished with his first 100+ yard rushing game in Week 9. The Jaguars have allowed seven rushing touchdowns to running backs over the last three weeks. This is an easy matchup, regardless of the league you're in.
Donald Brown (vs. Rams): If Trent Richardson doesn't play, Brown is a great flex/RB2 play. Even if T-Rich suits up, the Rams just gave up 188 yards and three rushing touchdowns to the Titans. Brown is outplaying everyone in the Colts backfield, and he needs more touches.
Jordy Nelson (vs. Eagles): The injury to Aaron Rodgers probably led many owners to bench every Packers receiver immediately. That's not the route you should take. James Jones can be benched, but Nelson is the top target in this offense, and he's facing an Eagles secondary that gives up the most fantasy points to opposing wideouts.
Lance Moore (vs Cowboys): Marques Colston is in jeopardy of missing another game, leaving Moore to see an expanded role once again. The Cowboys have allowed eight touchdowns to wide receivers this season, and Moore looks impressive since returning from injury. He's worth at least a flex play.
Riley Cooper (at Packers): When Nick Foles is under center, Cooper is going to eat. He hauled in five passes for 139 yards and three touchdowns last week with Foles starting against the Raiders. The duo obviously has a strong rapport, and owners will want Cooper in with Michael Vick likely out another week.
Timothy Wright (vs. Miami): After two straight games with a touchdown reception, Wright looks like a viable starter for most leagues. He's the No. 2 option behind Vincent Jackson, and that won't change with Mike Williams hitting IR.
Garrett Graham (at Cardinals): Arizona has allowed at least five receptions to opposing tight ends in all but one game. Graham is a mediocre play at best most weeks, but you have to exploit this matchup. Case Keenum can get him the ball.
Brandon Myers (vs. Raiders): Honestly, Myers has been terrible this season for fantasy owners. However, he's facing his former team, and players seem to make the most out of these situations. Expect Manning to help his starting tight end shine in this special matchup. That all said, only play Myers is you're hurting at tight end.
Matt Ryan (vs. Seahawks): Seattle may be vulnerable against the run as of late, but their pass defense remains towards the top of the league, ranking second overall (179.8 yards per game). Ryan continues to struggle without key offensive weapons, and even though Roddy White says he's playing this weekend, it would be wise to temper your expectations. Ryan's offensive line played well last week. He did not. The turnovers are worrisome.
E.J. Manuel (at Steelers): The rookie finally returns for the Bills. Despite enduring a complete massacre last weekend, you can't expect the Steelers to gives up 400+ yards and four passing touchdowns again. Prior to facing Brady, Pittsburgh allowed one passing score in three games. Hold on off Manuel.
Carson Palmer (vs. Texans): He has at least one interception in every game in 2013. That's an impressive streak that will likely continue regardless of the opponent. The Texans don't force many picks, but Palmer is so mediocre these days that it's easy to bet on one or two coming Sunday.
Giovani Bernard (at Ravens): There are a few factors working against the explosive rookie. 1) He's questionable with a rib injury (yes, he's expected to play). 2) Offensive coordinator Jay Gruden is happy with the workload in the backfield, so Bernard isn't getting more touches. 3) The Ravens have allowed one rushing touchdown to opposing backs all year.
Ray Rice (vs. Bengals): On the other side of the field from Bernard, the former first-round stud has finally reached the breaking point with fantasy owners. Rice hasn't exceeded 75 rushing yards this season. He has three touchdowns in 2013. It's time to let go.
Le'Veon Bell (vs. Bills): Bell keeps grinding each game other. He's tough to sit because of his workload, but the rookie runner is facing a Bills team that hasn't given up one rushing touchdown to opposing backs all year.
Harry Douglas (vs. Seahawks): He's filled in admirably for Roddy White and Julio Jones, but it's hard to get excited about Douglas' situation in Week 10. Even if White plays, the Falcons are facing one of the league's top secondaries (already mentioned above).
Mike Wallace (at Buccaneers): Tampa Bay is letting Darrelle Revis get back to his old island. He's shut down opposing No. 1 wideouts over the past two games, and the Bucs will presumably put him on Wallace. We've seen Wallace score one touchdown all year so far. He doesn't typically rise to the occasion against stud cornerbacks.
Anquan Boldin (vs. Panthers): Boldin hasn't scored a touchdown since Week 4. The Panthers haven't allowed a wideout to score since Week 2. That should lead you to believe starting him isn't the best idea. Mario Manningham's return should benefit the veteran receiver, but the impact might not be seen immediately, especially against a vastly improved Panthers defense.
Heath Miller (vs. Bills): Tight end is not a deep position, and Miller is just another one of the lackluster options for your lineup. The Bills struggled with Jimmy Graham two weeks ago, but who doesn't struggle with that monster? Don't expect the same production from Miller, who has nine catches over the last three games and one touchdown in 2013.
Jared Cook (at Colts): Cook caught his first touchdown pass last week after remaining scoreless since the season opener. Sure, that's bound to happen every once in a while. Do you really want to trust a guy who averages scoring once every half season? Plus, the Colts have given up one touchdown to tight ends through eight games.
Coby Fleener (vs. Rams): Even with Reggie Wayne out, Fleener caught three passes in Week 9. The Rams haven't allowed a tight end to score since Week 4, and they average the second-fewest points allowed to the position.