Hilton had an underwhelming game at San Francisco with just two catches for 13 yards. Of course, the 49ers have a very good defense and the Colts played very conservatively in a shocking win.
Hilton has been dealing with his neck issue for a couple weeks, but it's not something that should be a major factor while he's on the field. This week, he gets to travel to Jacksonville and should have some success. The Colts are going to be without Ahmad Bradshaw, so they might not be as inclined to run the ball as much as they did in Week 3.
Fantasy impact: Hilton is going to have some nice opportunity here. The Jaguars can't stop anyone and Hilton is a good bet to catch a long TD. He's a low-end WR2 and could put up some serious stats. Reggie Wayne should also be busy and productive.