Lazio will be just as angry as their hosts after unexpectingly dropping points at the weekend.
The Mauro Zarate - Libor Kozak union is unlikely to get a second outing at the San Paolo, with coach Vladimir Petkovic expected to revert back to his tried and tested 4-1-4-1 formation.
Zarate will be lucky if he sees any action at all. Hauled off for an early bath on Sunday, Petkovic rounded on the striker for not making the desired effort. Given the whistling coming from the Curva Nord, most Lazio Ultras agreed. The one time flavour of the month in Rome could well be approaching his sell by date.
Hernanes has dazzled away from the Olimpico thus far, with three goals in two road trips. The Brazilian seems back to his best under Petkovic and along with Miroslav Klose, can definitely be looked upon as a possible matchwinner.
Neither side could muster a goal in last season's corresponding fixture. Should the Neapolitans fail to register for a second consecutive game, and if Lazio can take advantage, then the Eagles really can be looked at as Scudetto contenders.