Brandon Moss led off the inning with an infield single, recording only the second hit of the game for the A's. Cespedes, whose triple off of Scherzer in the second inning represented Oakland's only hit prior to Moss' dribbler, followed by clobbering a 2-2 fastball into the left field seats.
Scherzer retired the next three batters and ended his night with 11 strikeouts and two walks in seven strong frames.
Cespedes nearly spoiled the momentum he gave his team with the home run when he misplayed a line drive off the bat of Victor Martinez with two outs in the eighth. However, A's reliever Sean Doolittle struck out Alex Avila to render the error meaningless.
A's starter Bartolo Colon settled in after the rough first inning and struck out four in six innings. He scattered 10 hits, but did not issue a free pass.