Nix, who started at third base while Alex Rodriguez was given a day off, was plunked in his first at-bat by Toronto Blue Jays starter R.A. Dickey. Nix was immediately replaced by Mark Reynolds, who stayed in the game at the hot corner.
The injury happened during an eventful second inning, which also saw the ejection of Jays shortstop R.A. Dickey.
Nix, who turns 31 on Aug. 26, entered Wednesday hitting .236/.305/.311 in 302 plate appearances while spending time at shortstop, third base and second base. Nix is the prototypical glove-first utility player; he has a career .218/.289/.358 line and has never finished a season with an OPS+ of more than 86.
Nix will almost certainly land on the disabled list, and with Derek Jeter set to start a rehab assignment at Triple-A Scranton/Wilkes-Barre on Thursday, the Yankees will likely be forced to make a move that doesn't involve the star shortstop.