| Year | Team | G | GS | W | L | SV | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1995 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 8 | 2 | 2 | 0 | 7 | 10 | 1.80 | 1.50 |
| 1996 | 0 | 24 | 17 | 8 | 7 | 2 | 1 | 0 | 111.1 | 83 | 42 | 28 | 10 | 40 | 114 | 2.26 | 1.10 |
| 1997 | 0 | 27 | 27 | 11 | 10 | 0 | 1 | 1 | 168.1 | 124 | 82 | 73 | 23 | 62 | 160 | 3.90 | 1.10 |
| 1998 | 0 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 4 | 6 | 2 | 2 | 0 | 0 | 7 | 4.50 | 1.50 |
| 1999 | 0 | 27 | 27 | 10 | 8 | 0 | 1 | 1 | 163 | 161 | 84 | 82 | 17 | 53 | 137 | 4.53 | 1.31 |
| 2000 | 0 | 19 | 19 | 7 | 7 | 0 | 1 | 0 | 109 | 115 | 64 | 58 | 9 | 34 | 93 | 4.79 | 1.37 |
| 2001 | 0 | 11 | 11 | 6 | 2 | 0 | 2 | 1 | 71.1 | 64 | 34 | 31 | 10 | 17 | 49 | 3.91 | 1.14 |
| 2002 | 0 | 13 | 10 | 4 | 2 | 0 | 1 | 0 | 74.1 | 55 | 20 | 15 | 6 | 12 | 44 | 1.82 | .900 |
| 2003 | 0 | 11 | 11 | 5 | 1 | 0 | 1 | 1 | 76.1 | 57 | 19 | 16 | 3 | 12 | 54 | 1.89 | .900 |
| 2004 | 0 | 16 | 13 | 5 | 3 | 0 | 0 | 0 | 73 | 80 | 50 | 46 | 13 | 30 | 46 | 5.67 | 1.51 |
| 2005 | 0 | 4 | 4 | 0 | 3 | 0 | 0 | 0 | 22 | 33 | 18 | 17 | 6 | 3 | 11 | 6.95 | 1.64 |
| 2006 | 0 | 4 | 4 | 2 | 2 | 0 | 0 | 0 | 23 | 31 | 14 | 13 | 2 | 6 | 14 | 5.09 | 1.61 |
| career | Total | 32 | 7 | 4 | 6 | 0 | 0 | 0 | 72.2 | 80 | 58 | 51 | 8 | 35 | 38 | 6.32 | 1.58 |
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| November 1, 2006 | Opted for minor league free agency. |
| May 19, 2006 | Suspended by the MLB for 50 games for testing positive for a performance enhancing substance. |
| March 21, 2006 | Assigned to minor league camp. |
| January 5, 2006 | Signed by the Pittsburgh Pirates to a minor league contract. |
| October 27, 2004 | Opted for minor league free agency (six-year f.a.). |
| May 30, 2003 | Exercised the Japanese claus in his contract and will join the Kintetsu Buffaloes. |
| March 2, 2003 | Assigned to minor-league camp. |
| December 3, 2002 | Re-signed as a minor league free agent by the St. Louis Cardinals. |
| August 30, 2002 | Designated for assignment. |
| August 24, 2002 | Contract purchased from Memphis (AAA). |
| July 11, 2002 | Acquired from the Cleveland Indians. |
| July 11, 2002 | Assigned to Memphis (AAA). |
| June 27, 2002 | Outrighted to Buffalo (AAA). |
| June 25, 2002 | Designated for assignment. |
| June 7, 2002 | Contract purchased from Buffalo (AAA). |
| March 7, 2001 | Assigned to minor league camp. |
| January 5, 2006 | Signed by the Pittsburgh Pirates to a minor league contract. |
| June 15, 2004 | Signed by the St.Louis Cardinals to a minor league contract. |
| March 22, 2004 | Signed by the Baltimore Orioles to a minor league contract. |
| May 30, 2003 | Signed by the Kintetsu Buffaloes (Japan). |
| July 11, 2002 | Cleveland Indians traded Nerio Rodriguez to the St. Louis Cardinals for Neil Simoneaux. |
| May 14, 2001 | Signed as a free agent by the Cleveland Indians. |
| November 17, 2000 | Signed as a free agent by the New York Mets. |
| March 30, 2000 | Claimed on waivers by the Boston Red Sox from the New York Mets |
| March 28, 2000 | Claimed on waivers by the New York Mets from the Toronto Blue Jays. |
| July 31, 1998 | Toronto Blue Jays traded Juan Guzman to the Baltimore Orioles for Nerio Rodriguez and Shannon Carter. |
| December 6, 1994 | Selected by the Baltimore Orioles from the Chicago White Sox in the Rule 5 minor league draft. |
| February 2, 1990 | Signed as a non-drafted free agent by the Chicago White Sox in 1990. |
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