Wade had scored 14 points in the game before limping off the court with 5:04 left in the quarter. He also had four rebounds and two assists in 21 minutes for the East, who lost 148-143 loss to the West.
It is the same ankle that has been bothering Wade all week since hurting it against Boston last Sunday.
The Heat resume play Tuesday at home against the Kings. No word yet on the severity of the injury and whether or not he'll play in that game.
For more updates on Wade and more Heat-related All-Star talk, keep an eye on Peninsula Is Mightier.