The right shoulder injury forced him to miss three games earlier in the season.
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Initially, the Lakers' medical staff said that their center was day-to-day. Los Angeles is in the middle of a seven-game road trip, so any time missed by Howard could be devastating. The Lakers already lost the first game of that trip and have a 20-26 record.
Howard first injured the shoulder in early January and missed three games before returning to the lineup. In 43 games for Los Angeles, Howard is averaging 16.5 points and 11.9 rebounds per game.
Pau Gasol is expected to start at center in his place.