The Lakers had no answer for Parker, who finished with 28 points on 9-of-20 shooting, adding seven assists and four rebounds. San Antonio got major contributions from Parker, Manu Ginobili and Tim Duncan, and Kawhi Leonard finished with 16 points and seven rebounds.
The Spurs shot a blazing 51.2 percent from the field and 50 percent from the three-point line.
For the Lakers, Dwight Howard led the way with 16 points and nine rebounds and changed numerous shots on the defensive end with four blocks. Steve Blake turned in a strong performance with 16 points, six rebounds and two assists. L.A. shot 45.1 percent from the field, but just 36.4 percent from the three-point line.
The injury bug continued to hit the Lakers, however, at a time where they are already paper-thin with the loss of Kobe Bryant and nagging injuries of Howard.
Blake exited the game in the fourth quarter with a strained hamstring, and Steve Nash returned for his second game of the playoffs, clearly laboring throughout the game. Nash struggled through his 31 minutes, ending with nine points and six assists.
The series will now shift to Los Angeles, where the Lakers will host the Spurs at 10:30 p.m. ET at Staples Center in Game 3. The home team in the NBA playoffs is 14-2.