The victory pushed Toronto's winning streak to four and snapped a five-game streak from the Pacers, who move into a tie with Oklahoma City for the best record in the NBA (25-6). Toronto also moved to an even .500 on the season (15-15).
The Pacers led by four at halftime behind a 26-14 second-quarter advantage, but the Raptors answered by scoring the final nine points of the third quarter to grab the lead. John Salmons scored all five of his points in that span.
Center Roy Hibbert led the Pacers with 16 points, but fouled out with 3:25 to play.
Toronto was able to force 22 Indiana turnovers, including three steals each from DeRozan and Terrence Ross. Ross also had 18 points to finish as the Raptors' second leading scorer.
Next up, Toronto has three straight on the road, capped by a rematch in Indianapolis. The Pacers return to action Saturday at home against the Pelicans.