After a week in which the Patriots' explosive offense had to do its scoring in limited time of possession, Tom Brady and the rest of the New England attack wasted no time putting points up on the Bills.
Brady threw three touchdowns, all before the 11:00 mark in the third quarter, and the Patriots romped past the Bills, 34-3.
Brady also broke the NFL record for consecutive passes without an interception, running his tally to 310 on the season. Brady's last interception came in October against the Ravens.
Rob Gronkowski caught two of Brady's touchdowns. Danny Woodhead added another on the ground.
The Bills scored first in the game, getting a Rian Lindell field goal midway through the first quarter, then allowed 34 unanswered points.
The 13-2 Patriots clinched home field advantage throughout the AFC playoffs with the win. The Bills got that much closer to a top-five pick in the 2011 NFL Draft, falling to 4-11.