Jacobs missed team practice on Thursday because of the MCL sprain, the second practice he's missed this week.
The good news for New York is two-fold. First, they've relied heavily on Ahmad Bradshaw in the run game this season. He has 17 more carries than Jacobs and has average a whole yard more per rush. The Giants will also happily welcome the 1-3 Seahawks to New Meadowlands Stadium for a game New York should manage to win without their big back.
As for the fantasy spin, expect Bradshaw to get a few more touches. He and Jacobs each have two touchdowns this season, but Bradshaw will get the goal-line carries on Sunday. Running back Danny Ware should get Jacobs' touches and the Giants could activate seventh-round draft pick Da'Rel Scott.