The Giants won the coin toss and deferred the opening return to the 49ers. The opening kickoff was returned 15 yards by Kendall Hunter to the San Francisco 23 yard line. Frank Gore gained four yards on a run, then caught an Alex Smith pass for a first down that took the Niners to the 33 yard line. Hunter was tackled for a loss of one yard with lineman Mike Iupati being injured on the play. Smith then threw a short pass intended for Gore that fell incomplete and the home team was forced to punt it away.
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