NFL Week 6 picks and predictions: Bills vs. Cardinals

Greg M. Cooper-US PRESSWIRE - Presswire

The Arizona Cardinals, who opened the season 4-1, host the Buffalo Bills and their struggling defense on Sunday, leading most experts to predict an Arizona victory.

The Arizona Cardinals host the Buffalo Bills in Week 6, with Arizona looking to take advantage of Buffalo's defense (currently allowing an average of 35.2 points per game) to bounce back from a 17-3 loss to the St. Louis Rams. A look at picks and predictions from pundits, writers and NFL experts shows that most people expect Arizona to do just that.

Eight experts at ESPN.com are unanimous in picking Arizona, though several people have not yet made their picks. In addition to their human experts, ESPN's Accuscore simulation is calling for a Cardinals victory. The Bills get a vote of confidence at CBS Sports, where picks are made both straight up and against the spread. In both cases, Mike Freeman and Will Brinson see a Buffalo victory, while the seven other writers pick Arizona. At Yahoo! Sports, Jason Cole has a win for the Bills down, while Les Carpenter and the collected Yahoo! users predict a Cardinals win.

The Cardinals were able to open the season 4-0 before falling to the Rams. Judging by the picks, most people expect them to get back to their winning ways against Buffalo.

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