The Giants, 4-2, are winless against division opponents this season, while the 3-3 Redskins are coming off an impressive victory against the Minnesota Vikings.
RGIII and the Skins' last road game was a 24-22 victory against the Tampa Bay Buccaneers in Week 3.
While this NFC East battle could be a tough pick because of the familiarity many of the players on both sides have with one another, most experts agree that the Giants will earn a home victory and stay atop their division, as both Yahoo! and CBS Sports have unanimously selected the Giants to win.
But because these are two of the highest-scoring teams in the NFL, expect a back and forth battle that could come down to the final possession.