The Patriots opened as six-point favorites, but the line has shifted as bettors put their money on New England to cover. They're 4-3 straight-up and against the spread this season, while the Rams have offset their 3-4 record by going 5-2 against the spread. The Patriots have won their games by an average of 7.7 points per contest, so even the current line is favorable in that regard. However, the Patriots have had all sorts of problems against NFC West teams this season, losing to the Arizona Cardinals and Seattle Seahawks already.
The over/under for the game is set at 47. An average of 53.3 points have been scored in the Patriots' seven games this season, while the Rams and their opponents have combined to score just 38.7 points per contest.
To view betting lines for games from across the league, visit SB Nation's NFL odds page.