Despite coming fresh off their bye week and facing a team that is just one win better than them in the standings, the Colts are still big underdogs against the Green Bay Packers in Week 5. After opening as 7 1/2-point underdogs, the line has since slimmed but not by much, as the Packers are 7-point favorites.
The Packers haven't been very good against the spread as of late, though, particularly against the Colts, whom they are 2-5 against when factoring in the spread.
Perhaps the safer bet is the over, despite the 48 1/2 point over/under total being one of the highest of the Week 5 matchups. The Colts and the Packers have each hit the over in their first four games, making them a combined 8-0 in favor of the over.
In four of the last five matchups between the two teams, the total has gone in favor of the over as well.