Peyton Manning has plenty of experience playing in New England against Tom Brady. In fact, he's taken eight career trips to New England to play the Patriots, but this will be the first time in his career he's done so in a Broncos jersey. And he'll do so as a big underdog in Week 5. The 7½-point spread in favor of the Patriots is the third largest margin of Week 5, despite the teams sharing identical 2-2 records.
It has been the Broncos that have dominated the matchup for a while, although the Patriots have bested them in the last few games. In the last 23 games between the two AFC teams, the Broncos have won 17 straight up and 16 against the spread. However, the Patriots are 3-1 both straight up and against the spread in the last four games of the series.
The game also features Week 5's highest over/under total at 51½ points. With New England leading the league in scoring and the Broncos averaging the seventh most in the NFL, the defenses will have their hands full trying to accomplish the under.