Ed Mulholland-US PRESSWIRE - Presswire

NFL odds and lines for Week 5: 49ers are big favorites

After three weeks of losses, the public came roaring back in Week 4, buoyed by the Patriots and 49ers. Will they be rewarded for backing heavy chalk like the 49ers and Giants this time?

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25 Total Updates since October 4, 2012
  • Important 24
  • Articles 25
  • All Updates 25

Matt Cassell injury: Chiefs QB injuuredt by Ngata

Kansas City Chiefs quarterback Matt Cassel was knocked out of the game against the Baltimore Ravens on a hit by Haloti Ngata.

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Rivers photobombed by patriotism at its finest

Philip Rivers, an Eagle, and America.

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Watch the letdown game in Minnesota

Minnesota has won consecutive games as an underdog and now returns home in the rare role as favorite. They lay 5.5 points against the visiting Tennessee Titans Sunday in Week 5 betting action.

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Seahawks look to win again as road underdogs

Seattle wins at home and loses on the road, but the betting trend on the Seahawks involves their play as an underdog. They lay three points to Carolina in Week 5 betting.

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Signs point to a Pittsburgh win

The battle of Pennsylvania sees a clash of streak on Sunday but the total may be the most obvious betting trend in Week 5.

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Browns are losing, but still profitable

Cleveland continues its loser reputation in 2012, but they have a much different rep with NFL bettors. Despite losing on the road and as a dog, they have been a profitable bet.

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Jags are home underdogs against Bears

The Bears are fighting a pair of negative trends as they visit Jacksonville as 5.5-point road chalk.

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Can the Saints finally win a game?

San Diego has performed well as a road dog, but they visit a Saints team that has motivation to win and win big in Week 5.

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Colts await Packers in Indy

The Packers are motivated road favorites at Indianapolis in Week 5, but they face a Colts team that has covered three straight as a home underdog.

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Chiefs can't protect Arrowhead

The Chiefs play UNDERs at home and Kansas City vs Baltimore games at Arrowhead have historicaly been UNDERs. Why the interest in betting OVER 46.5 this week?

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Redskins lose as home underdogs

Washington rides a losing streak as a home underdog, while Atlanta gets the job done as a favorite. Can the Falcons cover a small road spread in Week 5?

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Hasselbeck, Titans 5.5-point underdogs vs. Vikings

The Tennessee Titans will turn to Matt Hasselbeck on the road Sunday against the Minnesota Vikings, hoping he can lead the 5.5-point underdogs to an upset without starting quarterback Jake Locker.

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Jets host Texans as underdogs

The Houston Texans come to New York on Monday night to take on the Jets as significant favorites.

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Bengals 4-point favorites vs. Dolphins

The Cincinnati Bengals are riding a three-game winning streak, and as such are 4-point favorites against the Miami Dolphins, who have lost their last two games in overtime.

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49ers favored by 8 over the Bills

The 3-1 San Francisco 49ers are favored by eight points over the 2-2 Buffalo Bills.

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Bears favored to beat Jaguars

The Chicago Bears are the favorites entering the Week 5 matchup with the Jacksonville Jaguars.

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Matt Ryan, Falcons favorites on the road vs. Skins

Robert Griffin III and the Redskins are three-point underdogs as they host the undefeated Falcons in Week 5.

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Can Giants cover as heavy favorites vs. Browns?

The New York Giants, coming off a loss to the Eagles, return home to face a winless Browns team as nearly double-digit favorites.

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Brady or Manning in Week 5?

The total has gone over in four of Denver's last six games.

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Cam Newton, Panthers slim favorites vs Seahawks

The Carolina Panthers are 2-point favorites over the Seattle Seahawks in Week 5.

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Packers favored by a touchdown over Packers

The over has been the winning bet in four of the last five games between the Colts and Packers.

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NFL Odds Week 5: Ravens vs. Chiefs

Kansas City is 2-5 against the spread in its last seven home games.

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Eagles underdogs at Steelers in Week 5

The Philadelphia Eagles open as 2 1/2-point underdogs on the road against the Pittsburgh Steelers in Week 5.

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NFL Odds Week 5: Cardinals vs. Rams

The total has gone under in seven of Arizona's last eight games when playing St. Louis.

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