NFL picks Week 5: Bills vs. 49ers

Ed Mulholland-US PRESSWIRE - Presswire

While the 49ers are heavily favored against the Bills on Sunday, some NFL experts are picking Buffalo in an upset.

The San Francisco 49ers might be 9.5-point favorites in the Week 5 clash with the Buffalo Bills, but that hasn't deterred a handful of NFL experts from picking the Bills in an upset.

A majority of CBS Sportsline's expert team likes the Bills (2-2) in Sunday's game. Five of the website's eight experts pick Buffalo in an upset, while Pete Prisco, Clark Judge and Jason La Canfora like the 49ers.

ESPN's NFL expert crew stuck with the odds and picked San Francisco (3-1) across the board. Five of the network's 13 experts have yet to submit their picks for Week 5 however.

Mike Silver and Jason Cole of Yahoo! both like the 49ers on to come out on top.

SB Nation's own Joel Thorman picks San Francisco to down the Bills, 24-16.

Kickoff is scheduled for scheduled for 4:25 p.m. ET at Candlestick Park and the game will be televised on CBS.

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