A majority of CBS Sportsline's expert team likes the Bills (2-2) in Sunday's game. Five of the website's eight experts pick Buffalo in an upset, while Pete Prisco, Clark Judge and Jason La Canfora like the 49ers.
ESPN's NFL expert crew stuck with the odds and picked San Francisco (3-1) across the board. Five of the network's 13 experts have yet to submit their picks for Week 5 however.
Mike Silver and Jason Cole of Yahoo! both like the 49ers on to come out on top.
SB Nation's own Joel Thorman picks San Francisco to down the Bills, 24-16.
Kickoff is scheduled for scheduled for 4:25 p.m. ET at Candlestick Park and the game will be televised on CBS.