Harrison has been out of action since undergoing arthroscopic knee surgery in mid-August to repair his left knee, while Polamalu has been out since sustaining a calf injury in the season opener against the Denver Broncos. Both players returned to practice on Wednesday and have been able to fully participate in all drills.
However, defensive coordinator Dick Lebeau stated that while they may start, they may not play the entire game.
Running back Rashard Mendenhall was not included on the injury report and will be making his season debut on Sunday. He has been out since suffering a torn ACL at the end of last season.