The Eagles (3-1) are looking to remain a top the NFC East Division standings after downing the New York Giants, 19-17, on Sunday Night Football.
The Steelers (1-2) are coming off a bye week looking to improve on their disappointing performance in a 34-31 loss to the Oakland Raiders in Week 3.
This will be the first time the two teams have met in the regular season since 2008 when the Eagles beat the Steelers, 15-6. In early August, the Eagles defeated the Steelers, 24-23, in a preseason game at Lincoln Financial Field.
Philadelphia is led by running back LeSean McCoy, who's coming off an impressive 123-yard performance against the defending Super Bowl champions. Wide receiver DeSean Jackson has 20 catches for 333 yards.
Meanwhile, the Steelers are expected to get a huge boost to their lineups as running back Rashard Mendenhall, linebacker James Harrison and safety Troy Polamalu are expected to return from injuries. Pittsburgh hasn't played a game with all three players this season.
Game Date/Time: Sunday, Oct. 7, at 1 p.m. ET.
Location: Heinz Field, Pittsburgh
Betting Odds: Steelers (-3).
TV Distribution Map: The506.com