The Buffalo Bills and San Francisco 49ers are set to face off at 4:25 p.m. ET. The 49ers will be without a host of offensive players, while the Bills have a mixed bag of injuries at different positions.
- Tackle Cordy Glenn
- Safety Delano Howell
- Quarterback Tarvaris Jackson
- Defensive end Spencer Johnson
- Linebacker Kirk Morrison
- Guard Kraig Urbik
- Running back Johnny White
The 49ers will be without seven players as well, headlined by running back Brandon Jacobs, who injured his knee in the preseason. Jacobs had said earlier in the week that he hoped to make his season debut against the Bills.
A complete inactive list for San Francisco is below.