Graham rolled his ankle with 3:46 remaining in the first quarter on his only catch of the night. He sat out the rest of the first half before playing limited action in the second half.
It wasn't the only injury for the Saints. Defensive back Jabari Greer left the game and did not return with an injury that appeared to be either to his hip or his groin. Greer missed Week 1 with a groin injury.
Although the Carolina Panthers lost on Sunday, they were lucky enough to avoid any injuries.
The Tampa Bay Buccaneers were off.