Doing that appears to be a tough task, as the Colts are 10-point underdogs on Sunday, according to OddsShark.
Both teams have 6-3 records this season, but the Colts have been the safer pick against the spread. They have covered six times, while New England has done so five times.
Even without Manning or Luck last year, the Colts nearly knocked off New England, eventually falling, 31-24. Over the last 10 games between the two teams, both sides have won five times.
Both teams are playing some of their best football lately, as the Colts and Patriots both enter Sunday's game having won five of their last six games.
Kickoff is scheduled for 4:25 p.m. ET on Sunday.