This is the third straight game Sproles has missed due to a broken hand that required surgery earlier in November.
The Raiders are missing most of their backfield, with running backs Darren McFadden and Mike Goodson declared inactive for the game. Marcel Reece and Jeremy Stewart will fill in for the injured pair and the Raiders will once again lean on Carson Palmer's arm for most of the game.
McFadden suffered a high ankle sprain on Nov. 4 against the Tampa Bay Buccaneers and hasn't played since. Goodson also injured his ankle and hasn't played since the loss against the Buccaneers.
Wide receiver Darrius Heyward-Bey will play in the game after missing most of the Raider's practices this week with a hamstring injury.