Andrew Luck leads the eighth-most efficient passing team in the league (283 yards per game) into this one against a Buffalo team that can score on the ground or through the air. Quarterback Ryan Fitzpatrick has thrown for 17 touchdowns this year, while the Bills average the seventh-most yards per game rushing (140.8).
Yahoo! Sports likes the Colts to win at home, with all three of its experts going with Indianapolis.
Locally, Phillip B. Wilson of the Indianapolis Star also like the Colts at home, but warns that upsets might be coming this week.
The folks at CBS Sports, however, are not all on the Colts bandwagon. Five pick Indianapolis, but three (Clark Judge, Jason La Confora and Will Brinson) are taking the Bills.
Kickoff is scheduled for 1 p.m. ET.