Harbaugh had held off on naming a starter for Sunday's game throughout the holiday week. Kaepernick made his first career start last week against the Bears, due to starter Alex Smith's concussion. Kaepernick was impressive against a stout Chicago defense, completing 16 of 23 passes for 243 yards and two touchdowns, with no turnovers.
Sunday's contest is a rematch of last year's NFC divisional playoff game, won 36-32 by the 49ers on Smith's 14-yard touchdown pass to tight end Vernon Davis with just nine seconds left. This year's incarnation of the Saints, after beginning the season 0-4, are making a strong playoff push and a win over the 49ers would bolster their cause.
Kickoff for Sunday's game is scheduled for 4:25 p.m. ET from the Mercedes-Benz Superdome.