The lines now sit at six points in favor of Buffalo.
Both teams come into the game with losing records, though Jacksonville picked up its second win of the season last week against the Tennessee Titans. Buffalo is 2-2 at home, while the Jaguars are 1-4 on the road this year.
The total for this game is sitting at 45.5 points, and the Bills have shown this season that they can put up big numbers offensively. Jacksonville, on the other hand, has struggled in the department. Buffalo has scored 30 or more in three games this season, while Jacksonville has scored more than 20 just once in its last five games.
The total has gone over in five of Jacksonville's last seven games.
Kickoff is scheduled for 1 p.m. ET Sunday afternoon from Buffalo.