The Jaguars beat the Colts, 22-17, in their Sept. 23 contest. Since then, the Colts have gone 4-1, with all four wins coming by six points or less. Meanwhile, the Jaguars are 0-5, losing three of those games by 17 points or more.
All eight of ESPN's analysts who have their picks in are going with the Colts, who are currently the fifth seed in the AFC through a half-season of play. CBS Sports's eight experts agree, with the Colts taking a clean sweep in the predictions there, as well. Two out of Yahoo! Sports' three writers have made their picks, and both have chosen Indianapolis as their favorites to win.
Kickoff between the Colts and Jaguars is set for 8:20 p.m. ET. The game will be televised on NFL Network.