The line opened as an even pick 'em. As seen on both OddsShark and the SB Nation NFL odds page, some books have moved to favor Indianapolis by three points, while other lines have moved to 3.5 as money has come in on the Colts.
Despite a 22-17 victory for the Jaguars over the Colts in week three, bettors seem to be favoring the hot Colts. Jacksonville has lost five games in a row, while Indianapolis is on a three-game winning streak. Another factor moving the line is likely the consideration that Andrew Luck, fresh off a rookie-record 433 yards passing in week nine, will be facing a Jaguars' defense that is sixth-worst in the NFL.
The over-under point total is set at 42 points, which comes in almost eight points above the two teams' scoring averages. Indianapolis averages 20 points per game, while Jacksonville posts a league-worst 14.6 points per game.