Colon came back after missing two games, but hurt his left knee again and had to leave the game against the San Diego Chargers. The team returned to the awkward arrangement they'd had with him out, with all-Pro center Maurkice Pouncey sliding over from center to left guard and backup Doug Legursky handling the snaps. The line was generally ineffective as Pittsburgh struggled to move the ball before scoring three touchdowns with the final result more or less decided. Kelvin Beachum is already subbing in for an injured Mike Adams and Marcus Gilbert at right tackle, and first-round draft pick David DeCastro has yet to play a snap in his NFL career.
Cleveland and Cincinnati did not suffer any major injuries in their losses Sunday.