Cook has appeared in every game since the start of the 2010 season for the Titans, and was set to record a career high in receptions, having reeled in 44 catches through this week's game. But his year is done after getting hurt making a catch in the third quarter.
In other Titans injury news, wide receiver Damian Williams might not return this season due to his hamstring injury, while linebacker Mike McCarthy is expected back next week against the New York Jets and defensive end Scott Solomon waits word on an MRI on his knee.
Their opponent, the Indianapolis Colts, saw linemen Winston Justice and Samson Satele leave the game, but both are expected to be back by next week. Running back Donald Brown will probably be able to play as well.
For the Jacksonville Jaguars, wide receivers Cecil Shorts and Rashad Jennings missed their game against the New York Jets with concussions, as did defensive end George Selvie. The timetable for return on all three is unclear. Michael Brewster missed the game with a broken hand, and is considered questionable for the team's game next week.
The Houston Texans came away unscathed from their major loss to the New England Patriots, although cornerback Alan Ball and linebacker Brooks Reed missed the game. Ball was listed as questionable, but did not play.