Lions defensive tackle Nick Fairley headlines the inactive list after being held out of practice the entire week because of a shoulder injury. He will be replaced by Sammie Hill on the defensive line.
Detroit will also be without tight end Brandon Pettigrew, who will be replaced by Will Heller. Safety Ricardo Silva is also sitting out the game in Arizona, and Don Carey will get the start at strong safety.
For Arizona, tackle Dan Williams will miss the game for the Cardinals with a hamstring problem, and receiver Early Doucet will be out after suffering a concussion. On the struggling offensive line, Adam Snyder will start for the Cardinals at center while Pat McQuistan will get the nod at the right guard spot.
DT Nick Fairley, TE Brandon Pettigrew, QB Kellen Moore, OT Corey Hilliard, OT Jason Fox, DE Ronnell Lewis, S Ricardo Silva